DIPP Gene Expression Studies

The human genome consists of approximately 25 000 genes. The function of these genes may be studied one or few at the time, or at genome-wide level using microarray technology.

The overall objective of these studies is to identify gene expression patterns that characterize development of diabetes-associated autoimmunity and progression towards overt clinical type 1 diabetes. In particular, we aim at discovering predictive markers reflecting the disease activity preceding the seroconverion to autoantibody positivity or onset of type 1 diabetes. The obtained data may be used in future intervention studies. In addition, we develop novel data on the molecular mechanisms of type 1 diabetes. A blood sample is collected for these studies in a special tube.